Can you use AMD CPU with NVIDIA GPU?

AMD CPUs have become the new personal favorite for gamers due to their lower price than Intel CPUs. However, most gamers tend to prefer NVIDIA GPUs over AMD GPUs because of their higher performance.

So, the perfect combination for a gaming computer would be an AMD CPU paired with an NVIDIA GPU. But, a big question arises here is do AMD CPUs work with NVIDIA GPUs?

Yes, AMD CPUs work perfectly in combination with NVIDIA GPUs. You can use an AMD CPU with NVIDIA GPU without any performance issues as long as you get a compatible Motherboard, a good Power Supply unit, a desktop case or a laptop with good thermals and a high-end cooling system.

In this article, I will go through some of the reasons why AMD CPUs work with NVIDIA GPUs, the performance levels of the combination, and whether AMD CPU with NVIDIA GPU combination is better than AMD CPU and AMD GPU combination?

Does AMD CPU work with NVIDIA GPU?

Yes, AMD CPU works with NVIDIA GPU. In order to understand how this system works you need to understand the functioning of CPUs and GPUs.


CPUs and GPUs communicate over the PCIe bus. In order for a CPU and GPU to be compatible with each other, they need to have an architecture that follows the general rule of PCIe which is PCI Express x16 architecture, as either 3.0 or 2.0 (3rd generation/2nd generation).

The good thing is that Intel, AMD, and NVIDIA follow this strict rule so you can use any combination without running into problems. You can pair an Intel CPU with AMD GPU, an Intel CPU with NVIDIA GPU, an AMD CPU with NVIDIA GPU, and an AMD CPU with an AMD GPU.

Now, both AMD Graphics cards and NVIDIA Graphics cards have a similar architecture with some slight differences. When you plug in the AMD GPU or the NVIDIA GPU, the hardware details for each of them are controlled by the Graphics cards Display Drivers. That is why for optimal performance you need to keep your Graphics card drivers up to date.

Is AMD compatible with NVIDIA?

Yes, AMD CPUs are compatible with NVIDIA GPUs as long as you select a Motherboard that is compatible with both AMD CPU and NVIDIA GPU, a high-end Power Supply Unit (PSU) that supplies enough power for both the AMD CPU and NVIDIA GPU to function properly, a good thermal system and a high-end CPU cooling system.

The first thing that you need to use for the above combination is a compatible Motherboard. NVIDIA GPUs work with most AMD Motherboards that have got a PCIe x16 slot available i.e. they share the same connection ports.

ASUS motherboard

Most motherboards for gaming have a PCI Express x16, as either 3.0 or 2.0. For Nvidia GPUs, most current models have a PCI Exp. x16 3.0, however, they are backward compatible, so a 3.0 can work with a 2.0. You should be able to slot in whatever PCIe graphics card you want as long as you have got the latest BIOS and a sufficient PSU wattage.

Next up is the Power Supply Unit (PSU). This is very important because the AMD CPU and NVIDIA GPU combination requires a hefty amount of power to function properly. You need to select a great PSU that supplies enough power to both the CPU and the GPU.

Lastly, you need to select a desktop case with great thermals and a high-end Cooling system. If you’re using a laptop then make sure to check out reviews of the thermals and the cooling system for the laptop.

I am currently using an AMD Ryzen 9 5900HX CPU along with an NVIDIA GeForce RTX 3060 Graphics card and the performance is insane.

So yeah, my desktop is living proof that AMD CPU is compatible with an NVIDIA GPU.


If you select a compatible Motherboard, a high-end Power Supply Unit, good thermals, and a great cooling system then you won’t run into any performance issues whatsoever.

However, you could land into issues if you make a mistake while choosing any one of the above four.

If you select an incompatible Motherboard then your CPU and GPU won’t work together. This is the biggest mistake you could make. So, make sure the CPU and GPU are compatible with your Motherboard.

Next up, you need to select a high-end Power Supply Unit (PSU). I personally use the Crossair RM 850i PSU and it works like a charm. Your PSU should be good enough to supply an adequate amount of power to both the CPU and GPU for them to work properly.

If there are issues with Power Supply then it could lead to Overheating and component failures, including fuses, bridge rectifiers, diodes, and FETs.

Finally, you need a good enough cooling system with great thermals. The AMD CPU and NVIDIA GPU combination generates a lot of heat and that is why your cooling system is really important to get a constant FPS without any performance issues otherwise it could lead to CPU Throttling, GPU Throttling, GPU Artifacting, or in the worst case your GPU may get damaged.

Intel or AMD CPU with NVIDIA GPU – Which is Better?

I have personally found that Intel CPUs work better with NVIDIA GPUs but this combination is costlier than AMD CPU with NVIDIA GPU. AMD CPUs also perform really well with NVIDIA GPUs so it all comes down to what you can afford.


Intel CPUs are very costly and if you can afford an Intel CPU then you should definitely go with Intel CPU and NVIDIA GPU. If you are looking for a budget-friendly option then I would recommend you to go with an AMD CPU and NVIDIA GPU combo.

AMD CPU with NVIDIA or AMD GPU – Which is Better?

NVIDIA GPUs perform way better than AMD GPUs when paired with an AMD CPU. AMD GPUs have a lot of graphics card driver issues but the drivers in NVIDIA GPU are more stable and don’t have such issues.

Here is a video that reviews the gaming performance of an AMD CPU paired with an AMD GPU and an AMD CPU paired with an NVIDIA GPU.

As you can see from the above video, the NVIDIA GPU outperforms the AMD GPU in almost every case. You get much better FPS and there are no lags. That is why I recommend NVIDIA GPUs over AMD GPUs when used with an AMD CPU.

AMD CPU with NVIDIA GPU Laptops 2021

All the big computer manufactures have now come up with laptops having AMD Ryzen processors and NVIDIA Graphics Cards. Here is a list of the best laptops with an AMD CPU and an NVIDIA GPU.


The Alienware M15 Ryzen edition contains AMD Ryzen R7 5800H processor with an NVIDIA GeForce RTX 3060 6GB GDDR6 Graphics card. You also have the option to use NVIDIA GeForce RTX 3070 and NVIDIA GeForce RTX 3080 Graphics cards.


The Razer Blade 14 is regarded as the most powerful 14-inch gaming laptop. It has AMD Ryzen 9 5900HX processor with NVIDIA GeForce RTX 3060 Graphics card.

(3) ASUS ROG Flow X13

The Asus ROG Flow X13 has AMD Ryzen 9 5980HS CPU with Nvidia GeForce GTX 1650 Graphics card. You also have the option to use NVIDIA GeForce RTX 3080 in combination with the AMD Ryzen 9 CPU.

(4) ASUS – ROG Zephyrus G15

The Asus ROG Zephyrus G15 has AMD Ryzen 9 5900HS along with the Nvidia GeForce RTX 3080 GPU. This is one of the most powerful AMD CPU and NVIDIA GPU combinations you can currently get.


The Lenovo Legion 5 Pro has AMD Ryzen 7 5800H CPU and Nvidia GeForce RTX 3070 GPU. This combination runs most high-end games without any lags and is far cheaper than other AMD CPU and NVIDIA GPU combinations.


The Acer Nitro 5 has an AMD Ryzen 5-4600H CPU and Nvidia GeForce GTX 1650 GPU. It is a great choice for gamers looking for a budget-friendly gaming laptop that has an AMD CPU and NVIDIA GPU.

(7) HP OMEN 15

The HP Omen 15 is a 15-inch gaming laptop with an AMD Ryzen 7 4800H CPU and an Nvidia GeForce GTX 1650 GPU. It is another great option for a budget-friendly gaming laptop.

(8) HP PAVILION Gaming Laptop

The HP Pavilion gaming laptop has an AMD Ryzen 5 4600H processor paired with an NVIDIA GTX 1650 GPU, which is a solid pairing for 1080p gaming.

(9) ASUS TUF Gaming A15

The Asus TUF Gaming A15 laptop comes with a variety of AMD CPUs and NVIDIA GPU combinations. The options for AMD CPUs in this laptop are AMD Ryzen 7 4800H Processor, AMD Ryzen 9 4900H Processor, and AMD Ryzen 5 4600H Processor.

The options for NVIDIA GPUs in this laptop are NVIDIA GeForce RTX 2060, NVIDIA GeForce GTX 1650 Ti, NVIDIA GeForce GTX 1660Ti and NVIDIA GeForce GTX 1650.

Will an AMD GPU work with an Intel CPU?

Yes, an AMD GPU will be compatible with an Intel CPU as long as you select a compatible Motherboard with PCI Express x16, as either 3.0 or 2.0. You also need to select a high-end Power Supply Unit (PSU) that can provide enough power supply to both the AMD GPU and the Intel CPU.

Another thing to keep in mind is the Thermal and Cooling system. The above combination can generate a lot more heat than the native Intel CPU and NVIDIA GPU combination so make sure to use a laptop or desktop with a high-end cooling system.

AMD CPU with NVIDIA GPU for Deep Learning – Does it Work?

Yes, you can use an AMD CPU with NVIDIA GPU for running Deep Learning applications that require CUDA and cuDNN drivers but this isn’t recommended.

Most deep learning applications recommend you to use a powerful Intel CPU like Intel i7-6850K or the Intel i9-7900X along with a CUDA compatible NVIDIA Graphics card or an AMD Ryzen CPU with Stream Processors and a compatible AMD GPU like AMD Radeon RX 5600 XT, or the AMD Radeon RX 6700 XT or the 6900 XT.

There have been instances where people have successfully used an AMD CPU and AMD chipset with NVIDIA GPU to run deep learning applications by installing NVIDIA graphics drivers and the CUDA SDK that those deep learning applications require.

So, the AMD CPU and NVIDIA GPU combination can run deep learning applications but as mentioned earlier it is not recommended even though it is cheaper.


AMD CPUs work really well with NVIDIA GPUs. The combination is far cheaper than the Intel and NVIDIA combination which is why a lot of gamers prefer to go with them.

I have tried really hard to cover everything in this article but in case I missed anything you can comment it down below and I will include your suggestions in this article.

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